Microscopic leaks can be devastating to sterile injectables and biologics. This article explores Helium Leak Detection (HeLD), the gold-standard quantitative method that achieves $10^{-9}$ mbar·L/s precision. Discover how HeLD overcomes manufacturing variability and ensures container closure integrity (CCI) from design to cold chain transport, meeting ASTM F2391 standards.https://www.... https://www.heliumleak.com/