Chemotherapy was potentiated by E7449 and one agent experienced significant antitumor action in BRCA-deficient xenografts. In addition, E7449 inhibited Wnt/β-catenin signaling in colon most cancers cell traces, likely through TNKS inhibition. In keeping with this probability, E7449 stabilized axin and TNKS proteins leading to β-catenin de-stabilization and substantially altered expres... https://thomasz974pux6.azzablog.com/profile