You will find there's launch of norepinephrine through the descending inhibitory bulbospinal neurons that binds to alpha-2-receptors from the dorsal horn to minimize afferent pain transmission and deliver analgesia. For that reason, medication like clonidine that focus on alpha-2 receptors can influence the transmission of pain. : linked to, https://barryr726tef7.wikienlightenment.com/user